Product Identification
【Product Name】Dimethyl fumarate
【Synonyms】Methyl fumarate ;富马酸二甲酯
【CAS】624-49-7
【Formula】C6H8O4
【Molecular Weight】144.13
【EINECS】210-849-0
【RTECS】EM6125000
【RTECS Class】Primary Irritant
【Merck】13,4308
【Beilstein/Gmelin】774590
【Beilstein Reference】4-02-00-02205
【EC Class】harmful, irritant, sensitizing

Physical and Chemical Properties
【Appearance】White crystalline powder.
【Solubility in water】Soluble
【Melting Point】102℃
【Boiling Point】192℃
【Vapor Pressure】0.48 (25℃)
【Density】1.37 g/cm3 (20℃)
【Partition Coefficient】.62
【Heat Of Vaporization】42.9 kJ/mol
【Usage】Used to treat psoriasis.
【Vapor Density】5
【Refractive Index】1.4037 (110.7℃)

First Aid Measures
【Ingestion】Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
【Skin】Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
【Eyes】Get medical aid. Gently lift eyelids and flush continuously with water. Extensive irrigation is required (at least 30 minutes).

Handling and Storage
【Storage】Store in a cool, dry place. Keep container closed when not in use. Keep containers tightly closed.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification
【Ingestion】May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
【Inhalation】Inhalation of dust may cause respiratory tract irritation.
【Skin】Causes skin irritation. May be harmful if absorbed through the skin. May cause reddening of the skin.
【Eyes】Contact produces irritation, tearing, and burning pain. Causes severe eye irritation and possible injury.
【EC Risk Phrase】R 21 36/37/38
【EC Safety Phrase】S 26 36/37/39

Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear safety glasses and chemical ggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety ggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
【Respirators】Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Poison Class】4

Fire Fighting Measures
【Flash Point】91℃
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures
【Small spills/leaks】Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity
【Disposal Code】3
【Incompatibilities】Acids - bases - oxidizing agents - reducing agents.
【Stability】Stable under normal temperatures and pressures.
【Decomposition】Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Transport Information
【HS Code】2917 19 90