Product Identification
【Product Name】2-(4-Imidazolyl)ethylamine dihydrochloride
【Synonyms】Histamine dihydrochloride；组胺二盐酸盐
【CAS】56-92-8
【Formula】C5H11Cl2N3
【Molecular Weight】184.06
【EINECS】200-298-4
【RTECS】MS1575000
【RTECS Class】Drug; Reproductive Effector
【Merck】13,4739
【Beilstein/Gmelin】3624116
【Beilstein Reference】4-25-00-02049

Physical and Chemical Properties
【Appearance】White crystals.
【Melting Point】246℃
【Density】1.43 g/cm3
【Usage】Histamine is involved in local immune responses, regulating physiological function in the gut and as a neurotransmitter.

First Aid Measures
【Ingestion】Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage
【Storage】Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation.

Hazards Identification
【Inhalation】Causes respiratory tract irritation. May cause allergic respiratory reaction. May cause effects similar to those described for ingestion. Can produce delayed pulmonary edema. May cause respiratory sensitization.
【Skin】Causes skin irritation. May cause an allergic reaction in certain individuals. May cause sensitization by skin contact.
【Eyes】Causes eye irritation. May cause chemical conjunctivitis.
【Ingestion】May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause flushing followed by pallor, dizziness, fainting, fall in blood pressure, headache, rapid weak pulse, pain, and itching.
【EC Risk Phrase】R 36/37/38 42/43
【EC Safety Phrase】S 22 26 36/37/39 45
【UN (DOT)】3335

Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear safety glasses and chemical ggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
【Respirators】A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
【Exposure Effects】Effects may be delayed.

Fire Fighting Measures
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures
【Small spills/leaks】Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity
【Stability】Stable under normal temperatures and pressures.
【Incompatibilities】Strong oxidizing agents.
【Decomposition】Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Transport Information
【UN Number】3335