Product Identification
【Product Name】Methyl 4-chloro-3-oxo-butanoate
【Synonyms】4-氯乙酰乙酸甲酯
【CAS】32807-28-6
【Formula】C5H7ClO3
【Molecular Weight】150.56
【EINECS】251-230-5
【RTECS】AK5115000
【RTECS Class】Other
【Beilstein/Gmelin】1759939
【Beilstein Reference】3-03-00-01207

Physical and Chemical Properties
【Appearance】Clear yellow liquid.
【Solubility in water】Slightly soluble
【Melting Point】14 - 16℃
【Boiling Point】229℃
【Vapor Pressure】0.072 (25℃)
【Density】1.3048 g/cm3 (0℃)
【pKa/pKb】9.54 (pKa)
【Partition Coefficient】1.14
【Heat Of Vaporization】46.6 kJ/mol
【Vapor Density】5.19
【Refractive Index】1.459 (19 C)

First Aid Measures
【Ingestion】Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.

Handling and Storage
【Storage】Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use with adequate ventilation.

Hazards Identification
【Inhalation】Causes respiratory tract irritation. Can produce delayed pulmonary edema.
【Skin】Causes skin irritation.
【Eyes】Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Lachrymator. May cause chemical conjunctivitis.
【Ingestion】May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.
【Hazards】When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
【UN (DOT)】2810

Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear appropriate protective eyeglasses or chemical safety ggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
【Exposure Effects】Effects may be delayed.

Fire Fighting Measures
【Flash Point】103℃
【Autoignition】360
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
【Fire Potential】Combustible material: may burn but does not ignite ily.

Accidental Release Measures
【Small spills/leaks】Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Provide ventilation.

Stability and Reactivity
【Incompatibilities】Acids, bases, oxidizing agents, reducing agents.
【Stability】Stable at room temperature in closed containers under normal storage and handling conditions.
【Decomposition】Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
【Combustion Products】Fire may produce irritating, corrosive and/or toxic gases.

Transport Information
【UN Number】2810
【Hazard Class】6.1
【Packing Group】I; II; III